Video: Microbiome Expert: EAT THIS to Heal Your Gut & AGE IN REVERSE

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it would be hard Jesse to find diseases modern diseases that are not either initiated or exacerbated by the microbiome look what we're doing with rotorite reduction of skin wrinkles vaginal moisture boost and testosterone

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acceleration of healing restoration of a youthful immune response restoration of youthful muscle yeah you're right it's getting really powerful I hear this too often oh don't tell me about my I take a

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probiotic you know no but that's not good enough that's the least important thing you can do currently Dr Davis you've been involved in this

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health world for many many years now and I'm guessing you've played with your diet and tried different things and experimented to get to where you are today let's talk about what you're eating these days and what you're recommending

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to others well as you know lately in the last several years it's become clear from other people's science as well as their own that the microbiome is a major player that was for many decades just

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neglected you know Jesse wasn't that long ago people would be prescribed a course of antibiotics suffer through a few weeks of diarrhea and we just dismissed the whole disruptive of the microbiome as

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his nuisance as this curiosity and had no impact and because of course that's become uh declared that is not the truth it is the disruption of the gastrointestinal microbiome whether it's due to antibiotics or other factors

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is a major detriment to health and it has a major role to play in obesity type 2 diabetes cognitive decline and dementia coronary disease skin rashes

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depression anxiety you name it and the microbiome likely plays a role in at least in at least exacerbating if not outright causing that disease in the first place and so the diet that I currently follow

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and advocate is one that achieves a number of things but also helps to restore or rebuild as best we can in this world where we you know no matter what we do we're still exposed to glyphosate no matter what we

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do we know we're exposed to go to a restaurant you don't know what that that's in that food so as best we can in a modern world try to recreate kind of what's your great grandma did you know

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so uh the basic diet followers of course no wheat grains or sugars foods that never belong in the human diet in the first place especially wheat and Grains it was a mistake made ten thousand years ago and we paid a huge price in chronic

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health problems because of it uh replacing nutrients that are largely lacking because modern Habits Like magnesium because we have to filter drinking water that removes magnesium but indeed that we try to get from sun exposure and

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consumption of such things as eggs from birds and liver but a lot of us don't get outside or we wear clothes that covers the surface area we don't eat enough liver so address factors that

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um influence insulin resistance and inflammation and then address the microbiome specifically that means such things as lots and lots and lots of fermented foods that is uh

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lacto-fermented foods like kimchi and sauerkraut and fermented veggies very inexpensive very easy but A major advantage for health so and then of course nourishing microbes that are in

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your GI tract with various fibers and polysaccharides so it's really but if you know if your great grandma was here she would say oh Jesse that's how we're supposed to eat we just forgot because

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such things as dietary guidelines got in the way you said there the fact that wheat and grains are still off the menu for you you've been talking about the dangers of wheat for a long time now

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has that position changed it all over the year since it has been how long has it been since we belly came out 10 plus years dance evolved no if anything it's it's

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all more I'm all more resolved unfortunately the forces that try to sustain the status quo are very powerful it is a trillion dollar business it's backed by federal governments in Canada and in the US and

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elsewhere um because that's how you know this is how the world grew to seven billion humans if if if we were still hunter-gatherers or did something similar that is grabbed a spear ax or

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Club killed something while we gather roots and Toppers and berries and nuts and ate the diet programmed into the human genetic code there would be no more than a billion

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people on this planet so we've inflated it because of proliferation of industrial grains and soy and so I sad to say Jesse but this lifestyle of no

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weed no grains that restores magnificent Health including magnificent metabolic health blood sugar drops triglycerides drop blood pressure drops so many of the common chronic diseases that are treated

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with medication go away with wheat and grain elimination Amplified further by those nutrients that address insulin resistance vitamin D magnesium omegas fatty acidine and then the microbiome issues and so the people who follow my

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programs are slender young younger than their stated age that's one of the great effects of this lifestyle people say at 60 look like they're 45 or 40 or something like that

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and they look and move that way too but so if anything but it is an elitist stand you can't do this in Somalia or the Sudan right or rural China so so

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it is sad to say Not By Design but by accepting that humans made a huge mistake ten thousand years ago in misperceiving the seeds of grasses as food

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well there's some Nuance there I want to pick apart you've made it clear we're talking about wheat and all grains the ideal but for people who might be on All Greens including wheat right now or just

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somebody that wants to find a more moderate stance to live in the modern world where you know grains are everywhere let's talk about the different continuum because there's these different

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categories within that we have the Ancient Grains we have the gluten-free grains we have sourdoughs that have been fermented so what I'd like you to do as the expert in this area is take us

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through from bad to worse because again there's no good here but bad to worse and your stance on all the above that I mentioned yeah I think it's clear the worst of all

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is modern high-yield semi-dwarf wheat that is this thing concocted in essentially in a laboratory in the 1960s 1970s it looks different it stands about

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18 inches tall the stalk is very thick the seeds are very large and the seed head is very long and yield per acre is greater and that was that's why it was done it wasn't created to screw with us it was created to increase yield per

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acre for farmers and it did typically four to eight fold more per acre than traditional strains of wheat but that is when they changed it so dramatically in appearance and biochemically they change

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the effects on humans one of the effects for instance is Farmers wanted better resistance to pests like molds and insects and so they selected strains of wheat that were enriched in wheat germa

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gluten and not gluten but a gluten in meaning agglutination of blood blood clotting and so they had modern wheat is enriched in wheat or glutenant but wheatrima gluten is a very potent bile toxin

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and it also um has other toxic effects in the body so they've increased it they did for pest resistance not to screw with you but inadvertently made it much more toxic than modern wheat plant likewise

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phytates phytates are also pest resistant compounds in wheat and Grains and they chose strange with greater phytate content but phytates we know bind minerals in your gut like calcium

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and magnesium and iron and zinc and you poop it out and so that's why there's a lot of iron deficiency anemia particularly in females it's odd that it affects females more so than males um so it's very toxic and cause mineral

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deficiencies they change the structure of the Glide in protein that's the thing that drives autoimmune diseases it's the thing that gets partially digested to four or five amino acid long peptides that go to the brain and stimulate

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appetite it's an appetite stimulant so modern wheat is so different and inadvertently they Amplified the toxicity so that's the worst little less worse would be traditional

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strains of wheat whether it's the wheat from 1950s or the week from 19th century or even if you go way back in Middle Ages or Biblical times where you had strains like Ember or iron corn very

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different so the traditional wild growing wheat iron core is a 14 chromosome plant modern wheat high-yield semi-to-art has 42 chromosomes to illustrate what that means so Jesse as a

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member of the homo sapiens species has 46 chromosomes I have 46 crumbs that your listeners have 46 chromosomes but modern wheat has 42 chromosomes the traditional ancestral form of week 14

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chromosomes it's very different so traditional strange wheat I wish there are hundreds of different strains a little less toxic we go back way back to Emma and then einkor and einkorn the

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original strain a little less toxic we go to other non-wheat strains like barley barley and Rye are essentially identical in wheat genetically they're they're closer than humans are to

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chimpanzees so they're very very close so those are almost just as toxic as as wheat then we get to the other grains people don't think of grains this way but they're promiscuous they're genetically

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promiscuous so they share a lot of genetic traits so uh grains that aren't aren't that all that popular like Millet or triticale uh still share some of

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these effects but we're getting less and less harmful we get all the way down to the most benign which is rice because rice a lot of the adverse effects of grains come by proteins because we're unable to digest fully digest all the

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proteins and Grains rice is about one percent or less protein it's mostly sugar but that that highlights the problem with rice that it's mostly sugar and of course more recently it's been

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found that rice is a concentrator of arsenic so such products as rice milks get often give them to children are very toxic so I I believe the USDA is contemplating Banning them

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and so but there's there's no no place in that Spectrum where we could argue grains are good there are various shades of less bad it's kind of like low tar cigarettes low tar figure filtered

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cigarettes do we get to a point where we've removed the tar and you use a filter and now cigarette smoking is healthy for you so not really small quantities of rice are probably safe small quantities of uh

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grains like Millet amid probably okay uh which when they become dominant but if you get to the most toxic end like high yield semi-dwarf wheat those are really toxic personally if I have a if I

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get exposed to a breadcrumb I'm not exaggerating I get quite ill for about a day um I have a daughter-in-law who's got celiac disease it takes just a spoon that contacted maybe a roux or grave

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with a little bit of and she'll be sick for about a week she can't she's got joint pain abdominal pain diarrhea and other things and so it's it's a reminder just how toxic it can be so a lot of us

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who've been wheat and grain free for a number of years you know you go to a restaurant you ask them on gluten-free we have to use that terminology right because they don't restaurant people don't understand wheat and grain free and they get confused by the gluten-free

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thing as you point out gluten-free foods are horrible they're horrible because they're typically made processed gluten-free foods with cornstarch tapioca starch potato flour and and um um where I blank in this fourth

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cornstarch rice starch tapioca starch and potato flour and those uh so wheat products because of the envelopectin a carbohydrate raise blood sugar higher than nearly all other Foods the only

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foods that among the very few foods that raise blood sugar even higher cornstarch rice starch tapioca potato flour so people who say oh I'm doing your program I gain 30 pounds and my Ambience gotten really big my

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blood pressure went up my triglycerides went from 150 to 350. are you eating gluten-free price yes I am of course gluten-free processed foods are criminally bad for you yet they're often

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touted as being healthier for they are not healthier they're they have a different set of toxicities but they are definitely not good for you oh this is a naturally gluten-free food if it's an avocado it's glued up that's great if

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it's a piece of pork a pork chop gluten-free that's great so natural gluten-free is fine it's it's what the food industry calls gluten free baking mixes Bagels kick cake mixes uh

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all that stuff that's the bad stuff and it's very destructive you mentioned the fact there your daughter-in-law reacts terribly as a Celiac you said yourself you react even to a little bit of weed

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or gluten you can specify but are you Celiac too you know I think I am I've never had formal testing because I I followed lifestyle anyway and you know what they say if you want to be tested you have to

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re-expose yourself for several weeks to generate positivity well there's no if I went back on wheat I would be sick as a dog I would have skin rashes I'd become a type 2 diabetic as I was many years

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ago not anymore uh uh gastrointestinal distress abdominal pain anxiety panic attacks small LDL particles coronary disease

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high triglycerides fatty liver in other words in order to prove it to myself I'd have to destroy my health and now thank Lord that's reversible not always though so you know if you if you generate

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coronary disease because of a big spike in small LDL particles that's what the amylopectin a of wheat and grain does so I I ironically Jesse you know we were talking cut fat eat more healthy whole grains that is a formula to generate

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heart disease and yet no one's apologizing for that that science is quite well sorted out by the way it's not my speculation that science uh has been sorted out and has corrupted been crowded numerous times

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starting with such people as Ron Kraut Dr Ron Krause a University of California Berkeley and other groups they have shown that it's the consumption of wheat grains and sugars that is a huge provocative agent for the formation of

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small LDL particles the real cause of heart disease that LDL cholesterol is a crude indirect marker four we can measure small LDL particles and other factors that cause heart disease but

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Pharma doesn't make money from it because there's no profit making drug for it when you start to do the real test for uh heart disease by the way which is just lipoproteins and I use the NMR nuclear magnetic resonance like

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protein testing it becomes immediately obvious that heart disease is a disease of diet has nothing to do with the need for drugs nothing nothing to do with so that's why they maintain this this

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fiction that you must treat cholesterol this crude outdated marker that should have been abandoned decades ago because it it's so it's such a lousy marker it gives the appearance that you need a

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drug to reduce it well the sad thing is people that are actually taking the time to follow the dietary guidelines they're going to be misled down this path which in and of itself takes energy and it

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makes sense people would trust the higher ups so it's it's really a messed up system and I don't know what's going to change it things like what you're doing right now talking to people who think who don't

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just take the status quo or the prevailing wisdom as as fact you know in the us alone 80 million people take a Statin cholesterol drug and there's been no reduction in cardiovascular events and your hospital uh throws a party

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because they just added 100 billion dollar wing for cardiovascular disease so cardiovascular disease is the number one Money Maker for the Health Care System there's very little incentive

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to reduce heart disease risk and yet reducing risk for heart disease is easy it's simple it's straightforward and has nothing to do with prescription drugs it has to do with some basic

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issues like not consuming something with the amylopectin a as in wheat and grain that spikes up small allele particles not having insulin resistance very easy by the way not having inflammation

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silent inflammation very easy by the way and most recently added to the list in the last few years is address the microbiome the gastrointestinal microbiome and thereby the phenomenon called endotoxemia all that means is a

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disrupted gastrointestinal microbiome results in release of something called endotoxin from fecal microbes that is able to cross into the bloodstream endotoxemia that's a major driver of all

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kinds of disease including coronary disease and stroke breast cancer skin rashes rosacea psoriasis brain effects like cognitive impairment Parkinson's

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disease anxiety depression in fact it would be hard Jesse to find diseases modern diseases that are not either initiated or exacerbated by the microbiome well let's take that story and go even

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further you talked about the endotoxin what I'm assuming you're referring to there is the LPS so let's get into the details the physiology how that's produced the way I see it that's actually a normal part of

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our digestion when it's in check but I'll have you talk about that and then when things go awry I think the biggest problem comes so there's there's grades of disruption of

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a gas intestinal microbiome so some people just have disruption of the species in the colon where microbes are supposed to be loss of beneficial species beneficial species do good things or did good things for us

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including suppress the fecal microbes these are microbes like E coli and salmonella and campylobacter which many people recognize because those are also

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the microbes of food poisoning so let's say you went to a fast food restaurant and the kids serving your food just moved his bowels and didn't bother to wash his hands so he just gave

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you a serving of E coli or they serve you some chicken that was undercooked but sat on a cutting board too long it has salmonella so you take those and those those species E coli salmonella

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campylobacter and others live in your colon we have them and they live there quietly but when you ingest them in some contaminated food is when you get nausea vomiting abdominal pain

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diarrhea and get quite sick now wait a minute if those microbes can live quietly in your colon why do they make you so sick when they well it's a reflection Jesse that fecal microbes are

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not tolerated in the upper GI tract and so one of the things that's happened in a lot of people as you likely know we lose the suppressive beneficial microbes in the colon fecal microbes

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start to proliferate but even more remarkably they ascend into the 24 feet of small intestine now the small intestine is not well adapted to having trillions of fecal microbes a colonists but not the small intestine small

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intestines is by design a place where you absorb things it's permeable so that you absorb amino acids and fatty acids and vitamins and minerals but when fecal microbes colonize the small intestine

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trillions of them you know they only live for a few hours they don't live for years or decades so there's huge turnover trillions of microbes and when they die as you know one of the components there's a number of of

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uh components that they shed one of the most important is the LPS endotoxin as you know there's other things too lipotychoic acid and some others but LPS endotoxin being the dominant one from fecal microbes so you have this flood of

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this endotoxin into the small intestine small intestine permeable endotoxin able to enter the bloodstream first enters the portal circulation portal venous circulation that drains to the liver so your poor

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liver takes a beating a beating it's one of the big contributors to fatty liver and non-alcoholics data hepatitis and cirrhosis but a lot of those endotoxins also get to the systemic bloodstream and

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play a role in all those conditions diabetes heart disease dementia skin rashes but it's now clear over the last 15 years this science is maturing to tell us that microbes in the GI tract

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but especially when they ascend into the small intestine uh that's how they export their effects to other parts of the body Jesse I thought this was uncommon I thought this idea that fecal microbes could colonize the upper GI

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tract um was a sibo small intestinal bacterial overgrowth I was guilty of things was uncommon or rare until this came out the the air device this is the old one this is the newer

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one this one measures hydrogen gas on the breath you blow into it it talks to your smartphone zero to ten or this one here's newer one which measures hydrogen gas and um uh methane and

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people don't have to buy these things but as I when it came out about 2018 I got a hold of it and it became clear the inventor is a PhD engineer and he didn't fully understand what it was he inventor

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I called him I said uh Angus this is not what you think it is I'm telling the inventor but good guy it's a it's a mapping device it can help you determine where microbes

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are living so it's not a detection device so much it's a mapping device you can use so your colon is supposed to produce hydrogen gas what you want to know is if there are

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microbes in the upper GI tract stomach do a denim jejunum that are can produce hydrogen gas so you do a baseline there's a whole prep and all that but just for the sake of brevity so you test

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the Baseline let's say one 1.2 0 to 10. and then you ingest something microbes metabolize we use inulin because most unhealthy microbes love inulin so maybe a couple teaspoons of England your

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coffee and then 30 45 minutes later test again 9.8 well if you can't that anyone couldn't get your colon fast enough to be metabolized the hydrogen gas so that

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has to be in the upper intestines up to about 90 minutes Beyond 90 minutes we don't know if it's distal ilium or colon so it's it's very useful but the reason I tell you this is because once I got my

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hands on this device a lot of my followers did it became clear Jesse that small intestinal bacterial overgrowth using his mapping device was everywhere it was the unusual person who tested

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negative now you might say well maybe the device is flawed maybe the concept is flawed except that we addressed it the proliferation microbes in the upper GI tract and people say things like this

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or now I'm testing not 9.8 but 1.3 or something like that and my weight loss Plateau broke or my rheumatoid arthritis finally went away completely it got better when with wheat grade elimination

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some of those other things but now I went away I stopped the last drug my depression find the lift my panic attacks finally stopped in other words we saw some residual health problems

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disappear so I become convinced and these data exist that not my data other people's data studies like this if we take people with uh irritable bowel syndrome

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What proportion will test positive for sibo so there's 60 to 70 million people in the US alone with irritable bowel syndrome and results vary with the study but roughly about 40 percent of those

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people test positive receivable so 40 of 60 to 70 million words 24 30 million people right there how about obese there's something like uh I've got the exact now 130 million

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Americans who are obese 50 will test pause at another 60 70 million to that list uh fatty liver 35 US population has fatty liver in Canada also uh well

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that's 35 of 300 plus million that's let's say I say 100 million 50 will test positive Placebo add another 50 million now there's some overlap obese type 2 diabetics with fatty liver but uh you

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add all the numbers up across neurodegenerative disorders autoimmune diseases type 2 diabetes Etc and you rapidly see wow conservatively estimated there's a

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hundred million Americans alone that means probably something like 10 million plus Canadians like one in three perhaps even one in two it's not uncommon and and if your doctor

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let's say the doctor all the doctor does for your diabetes give you drugs for blood to reduce blood sugar but didn't address the underlying sibo and endotoxemia he has resigned you to a

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future of weight gain diverticular disease emotional problems like depression and anxiety increased potential for cognitive impairment and

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dementia in other words if you don't get at the root cause or at least a major player in these all you do is pay attention to blood sugar you're doing that person a major disservice so you gotta address the contribution of

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a microbiome and by the way we have a very clean way to address that issue very different from the conventional should I tell you about it well we'll get to in a sec I want to make sure we're all on the same page here let me

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go over what you just what you just went over in detail and try and summarize it so bacteria from the large bowel are going up into the small and these are known as the quote unquote bad bacteria

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which are okay when they're in the large bowel but when they come up that's when they become a problem they die there part of their death is going to be this LPS from their cell wall because the

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small bowel is an absorber we're going to pull that into our bloodstream and then it becomes systemic and causes all these kind of problems do I have that right exactly right so you know if if you got real sick heaven

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forbid let's say you had a bladder infection mostly women get these things right so a woman has a bladder infection cystitis but then it ascends up the ureters into the kidneys and becomes pyelonephritis that you can get very

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sick and then if the bacteria let's say E coli or klebsiella then gets the bloodstream that's sepsis and you get very sick you might be put on a ventilator for

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acute respiratory distress syndrome you might go into kidney failure you could be Delirious have put on medications to keep your blood pressure up because you're going into shock I mean really really sick

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well if you measured LPS endotoxin in sepsis it goes up about a hundred fold over the normal situation so in endotoxemia like where you and I are talking about where we just have proliferation of microbes in the small

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intestine it goes up about two to four foot two hundred to four hundred percent so it's not as bad as a hundred fold of sepsis but it's still bad enough to have all these adverse effects so it's kind of like an EPA an instance of mini sepsis

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to make sure I have some of the details here right the bacteria that are dying in the large bowel these ones that went up to the small and this other story we were telling and they're producing LPS is any of that

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absorbed into the bloodstream remember before I said something about a normal amount of LPS that's what I'm getting at dlps that's produced in the large bowel does that stay there because the large Bell is you know thicker and designed to

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be mostly pulling things in so you're right some gets into the bloodstream is set especially from the ascending colon so some do get so there's a normal very low grade level of endotoxima that just

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occurs even in normal healthy people but it's the rise it's both the it's the rise in endotoxin level in the bloodstream through the permeable small intestine that that is I believe the

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biggest problem uh so our jobs is to recognize it you could use the air devices also such there's some very reliable what I call telltale signs that this is happening to

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you so symptoms of irrele bowel syndrome would be a very good sign irobal syndrome IBS is in in most cases sibo is this mislabeled uh people with

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fibromyalgia a very high likelihood maybe as much as a hundred percent have sibo and have it very bad people have fat malabsorption that is you go number two and you look in the toilet there's fat droplets floating or

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there's staining of the porcelain that's from that's from microbes in the duodenum way up high just after the stomach that block the action of pancreatic enzymes and bile and prevent you from digesting fats

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food intolerances people say oh I can't eat nightshades I can't eat fodmaps I can't eat histamine containing foods or I got IGG food intolerance testing and I

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can only eat these nine Foods or I can't eat these 42 other Foods very unnatural those are almost all examples of sibo and so eliminating

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those Foods is not the solution in fact eliminating those foods like a low FODMAP site may actually make the situation worse it provides near-term relief from gas bloody and diarrhea but it doesn't correct the situation it

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doesn't correct the fact you have 30 feet of fecal microbes living and dying and increasing the probability of your intestines and generating food intolerances

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at the the vast majority of food intelligence go away just like our great grandma's day right where your great grandmothers say Jesse we we didn't have any of these things we would eat food in

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fact food were sometimes scarce and we were grateful to have food no one had a list of 37 Foods they couldn't eat well before we get into how to solve this in a natural way which we're going to get into the details here

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let's talk about what's happening to that person which is super common as you've stated what is changing to allow that bacteria to come up what are the normal mechanisms is what I'm getting at to

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keep that in the large bowel that are going awry so it's the loss of microbes healthy microbes that suppress proliferation of fecal microbes loss of species like various lactobacillus species by

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photobacterial species fecalobacterium acromancia on and on on listeria unless Acacia long list literally hundreds of species but I believe it's my view it's

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mostly the loss of two lactobacillus roiteri and lactobacillus gasseri and the reason I believe that Jesse is because those two species are

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especially good at one surviving stomach acid and bile so you take say 100 billion most of it survives that's not always true for all microbes but those two are very good at surviving stomach

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acid and bile acid they're also unique in that they colonize the small intestine that's where the battle is being fought in the small intestine and these guys colonize the upper the small intestine

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where they take up residence and produce what are called bacteria sentence natural antibiotics effective against fecal microbes so we actually put this to use we

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ferment those two as a yogurt or other food and I regret calling yogurt people think oh I can go to the store and buy no no that's something entirely different this is something that looks and smells like yogurt but it's not the stuff you buy in the store we're going

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to just use this yogurt-like material to amplify bacterial counts to hundreds of billions hundreds of billions per half cup serving so we ferment lactose like muscles rotary and lactose gas right uh

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optionally add bacillus Kawaii lens bacillus quite lens is a Spore forming microbe and oddly makes the most delicious yogurt you ever had so so if you added the gas dry is not that tasty it's kind of bitter and the road rise a

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little bit sour so you add the bacillus quality Lynch you add some more bacteria in producing capacity and it makes it taste much better but it's optional but we take we make this yogurt ferment

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excuse extended fermentation because microbes don't have sex right right there's no male and female microbes they have asex reproduction so rotorite for instance doubles itself every three

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hours so if we dig a factory with a ferment for six hours you got nothing we're going to ferment for 36 hours we allow the microbe to double 12 times we perform something called flow cytometry on the yogurts and we had

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about 300 billion per half cup serving and you consume that and so far Jesse being Guided by these devices of about 50 people who've done this 90 have converted to negative

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for hydrogen gas it takes about four weeks sometimes longer so it's longer than the course of antibiotics and that by the way is the conventional solution if your doctor even knows what sibo is they'll give you a prescription for

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xifaxan or aphaximin it's very expensive it has risks like Clostridium difficile and or colitis which is very bad and you know what if if antibiotics got us here Jesse do you really want to take another

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antibiotic so uh what we're doing with the gas right in the rotori is also extremely safe because what we're really doing is replacing very important microbes that

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you should have had all along from your mom from birth breastfeeding contact but these microbes despite being such powerhouses of natural antibiotic production they're also very susceptible

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very vulnerable to Conventional antibiotics like amoxicillin so if you took amoxicillin 20 years ago for say an upper respiratory infection you wiped out your water ride your gas

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right and you open the door to fecal microbes to ascend all right so we make this quote unquote yogurt using these three species are the strains I'm assuming they are specific as well that we need

00:35:41

yeah I want to expand the menu of microbes that do this so we're doing some animal work and some human work but right now the strains we know work and by the way we should mention your listeners the reason we have to pay

00:35:54

attention to strain is because strain as well as species to make a difference so to illustrate so I've got E coli Jesse has E coli listeners have E coli but what if you ate lettuce contaminated

00:36:06

by cow manure and a different E coli strain you can dye that E coli same species E coli different strain so sometimes it's a life death difference literally sometimes it's not so it

00:36:18

depends so with regards to what we're doing with this what I call sibo Yogurt we know that the uh uh the I'm sorry about these names the atccc PTA 6475 strain Works available as

00:36:33

a product called biogaya uh either ask us Fortis or gastrous uh the bnr17 strain of lactobacillus gasseri

00:36:44

and the gbi 360 A6 strain of bacillus coagulants also known as the Canadian strain so people have to write this down you know it's it's in my super gut book it's in

00:36:56

my Dr davidsonvillehealth.com blog where you can get them also so these we only talk about microbes that are commercially available I have access to microbes that are research for research but I can't share them with people we

00:37:10

there's regulations over these kinds of things in other words I can't get it a micro from a repository that's been used to research and give it to you can't that because there's some safety issues involved so we can get commercially

00:37:23

available microbes but thankfully more and more microbes are becoming commercially available and so those three uh and the great thing is once you buy the three sources but you never have to buy it again because whenever we

00:37:36

ferment things whether it's yogurt or coconut milk or hummus or salsa you can ferment all kinds of different things you you get your microbe you ferment the first time and then you make your next

00:37:48

batch from a little of the prior batch so you don't have to buy it again so it's very and you can do this by the way also with your probiotics if you're sick and tired of paying fifty dollars for your probiotics ferment it and you get

00:38:01

those microbes in your yogurt or other fermented foods and you don't have to buy the probiotic as much maybe every so often you have to but you and there's all kinds of fermentation projects Jesse that are very inexpensive and extreme

00:38:13

fermented foods whether made from a probiotic or as sibo yogurt or whether you got it from some kombucha or starting culture or you just fermented from the microbes resident on the surface of a vegetable these are among

00:38:27

the most important things you can do for restoration people think probiotics are the most important no probiotics are the least important thing you can do is at least for the current crop of what's being sold is probiotics because modern

00:38:40

probiotics are mostly just haphazard slap Dash collections of microbes there's a lot of room for improvement in the probiotic world but for that reason the least important thing you do is a problem I point that out because people

00:38:54

say we'll talk about the microbiome they say oh no no no don't worry about me I take a probiotic well good luck with that it's because it's the least important thing you need to do and would you say in a similar way when we buy

00:39:07

fermented foods kombucha products that haven't been pasteurized that were getting this good bacteria it's kind of the Wild West there as well right I mean we're not getting we're talking here about all the nuances

00:39:20

you know the species and strain and and different amounts depending on how long you're fermenting my guess is it's kind of the wild west and and you're it'd be very difficult to be specific if you're just going to the

00:39:34

fridge and buying different organic fermented foods and trying to count on these companies to do it the right way for you and you getting what you want in the end yeah variety is key but the the odd

00:39:47

thing about fermented foods if we believe the Sonnenberg data from Stanford Erica and Justin Sonnenberg who published a very important study two years ago and they all they did was take your young people and ask them either

00:40:00

taking lots of Prebiotic fibers that is five percent nourish microbes like the inulin fos and onions and garlic and shallots or the galacto-algosaccharides and legumes so eat lots of those

00:40:12

another group eat lots of fermented foods like six to eight servings of fermented foods like kimchi kombucha kefirs yogurts Etc per day and by far the most Superior increase in diversity

00:40:25

the number of species were in the people who consumed lots of fermented foods now the peculiar thing about that Jesse is the microbes in fermented foods let's say some kombucha

00:40:36

or some kefir or some kimchi well those are species like leukanostok mesenteroides or lactobacillus plantarum or pediococcus spentacious or pity

00:40:49

acetylacticide so they're very specific mostly room temperature fermenting microbes but the peculiar thing is the microbes that reappear in your gastrointestinal

00:41:01

microphone are not those guys they're clostridious species their fecalobacterium species they're lactobacillus species so there's something that happens when fermenting microbes pass through your GI tract they

00:41:15

somehow set the stage for the restoration of lost microbes it's probable that they're there but they were latent in very small numbers essentially undetectable and that somehow the passage of fermented foods

00:41:27

allows them to get reinvigorated because there's a dramatic restoration of multiple species now there's more that people can do but just just the uh consumption of lots and lots of these fermented foods with these microbes

00:41:42

these room temperature fermenting microbes is somehow sufficient to restore tremendous species diversity of beneficial microbes that is so fascinating and now that we

00:41:53

know we're activating or bringing back these microbes that aren't even in the ferments are the ones that are actually in the fermented products populating as well so is it an activation of dormant

00:42:06

ones plus populating whatever was in that food or drink mostly don't so like the pityiococcus acetylacticide very very important microbe just passes through

00:42:17

does not take up residence they look at our stock misanthritis just passes through there are exceptions lactobacillus plantarum does take up residence and there's some others that do take up resin but for the most part it's not probably not from those guys

00:42:31

it's probably there's something unique about the passage of fermented microbes through the GI tract but so far no one's quite put their finger on what that process looks like but it's probably because you know you can't remember that

00:42:43

had the old uh miss that a pile of oily Rags is a source of rats I haven't heard that one no so the thousands hundreds of years ago they always say you had pile of dirty rags in the corner it would

00:42:56

make rats where rats came from what of course that's nonsense right you can't create rats Rags well same thing here we can't create microbes they're living creatures they had to come from somewhere they must have been latent or

00:43:09

maybe fermenting microbes somehow make you more receptive to acquiring microbes from other people from your kids from your spouse from friends from the dog

00:43:21

from doorknobs to tablecloth who knows so it's an uncertainty but if we believe the existing evidence it's fermented foods that are the most important thing you can do and you know what and you can tell

00:43:34

people who add fermented foods they'll start to say within a few days to weeks I'm feeling different I'm happier I'm more energetic I'm more regular my skin

00:43:46

is better so I mean there's very perceptible changes with the introduction with the reintroduction of fermented foods and you know if you talk to your if your great grandmother was still alive she would say oh yeah sure Jesse of course we did that's how we

00:43:59

that's how we stored food and it made food taste better too my dad would make sauerkraut in the basement all those stories and given that research the piece of curiosity it opens up for me is

00:44:11

the importance of having different fermented foods so kimchi kombucha you know regular sauerkraut this is getting very technical and Nuance for people so what I'm trying

00:44:24

to do is simplify it best we can and what I'm getting at with that is would the benefits be similar just to have a fermented sauerkraut in the fridge and have a good amount of that per day or are there different advantages given

00:44:38

what you just said about the fact that it's not what's in the fermented product but it's activating something in the system so a lot there but what I'm getting at is there are advantages of having kimchi

00:44:50

sauerkraut kombucha to have a diversity of different bacteria coming in will that activate different bacteria within or can we just stick to one fermented food variety is probably key

00:45:03

because there's different strains so let's say you like lactobacillus plantarum from fermented Meats but there's a different strain in the kimchi there's a different strain in the

00:45:17

sauerkraut and different strains different effects so there's that that also it helps to have a variety of Prebiotic fibers and related compounds from such things as root vegetables leeks dandelion greens onions garlic

00:45:30

shallots because they nourish microbes that that alone also changes the composition of the of the microbiome so variety is key I've seen this happen somebody says with a pretty black fiber for instance England fos you can buy

00:45:44

commercially you can get it from food but you can buy it commercially and they only use that and they actually generate adverse effects so variety is the key just as just as people did all

00:45:56

throughout human history we didn't eat one food we ate a variety of foods and so um I tell people don't make this harder than it is it's really very easy once

00:46:08

you get the hang of it but there's two general classifications of fermentation there's things that ferment at room temperature that would be like kombucha you can make it right in your kitchen counter or you're gonna ferment maybe some cucumbers

00:46:21

right on your kitchen counter then there's microbes that ferment at human body temperature so more towards like 37 degrees Celsius or 90 degrees Fahrenheit those are the species like rotary

00:46:33

gaseri other lactobacillus species bifidobacterial species those prefer human body temperature meaning they proliferate more rapidly at those temperatures and so if you're going to

00:46:47

just ferment on your kitchen counter you don't need any fancy equipment you do need to use filtered water that has no chlorine because it's antimicrobial you need to use salt to make a brine like two tablespoons per quart or per liter

00:47:00

non-iodized right because iodine is in the microbial and then you chop up your veggies put it in and you can rely on the microbes on the vegetable surface or you can use various things as starter cultures you can buy commercial starter

00:47:13

cultures if you have something already fermented let's say some commercial kombucha add a tablespoon of commercial kombucha you can add a little bit of a probiotic uh let me take that back because the probiotics are sometimes the

00:47:26

other kind but you can use all kinds of little starter ways if you use a starter culture it it ferments faster as opposed to fermenting from microbes living on the surface of that cucumber or radish

00:47:40

but then there's the human body temperature microbes and that you need a device you could make a yogurt maker could be an instant pot could be a sous-vide or some some device just to

00:47:52

keep the temperature at about 100 degrees Fahrenheit so the micro grows that's where people get a little confused uh but that's it's just a matter of temperature okay so coming back to my point there

00:48:03

there is Advantage having diversity because of different fibers and also the fact that different bacteria that are on these different ferments are going to activate different things in the system and we're going to

00:48:16

get to fermenting rotary and making our yogurt here in a bit we did cover that last time but I want to make sure we covered again it's really important and to see if there's any new nuances there you talked about starter it got me

00:48:29

thinking about starter for the Rotary last time we talked it sounded sounded like you had to order different bacteria and you alluded to that again earlier here it sounds like it's still a little

00:48:41

bit complex getting the different different bacteria to start the first time is there anybody because of this book in your talks or yourself putting together a commercial starter that includes

00:48:55

rotary and the other bacteria he talked about for the yogurt you know there is a company owned by a friend of mine by friends of mine called Cutting Edge cultures it's a Canadian U.S company and uh they

00:49:08

have not the combination but they have a rotary and they have a gas right that would work the bacillus coagulants if you choose to use it but I tell you if you ever made if you just want a really tasty yogurt

00:49:21

that tastes almost like thick whipped cream it's bacillus coagulants which surprised me bacillus quaglens is a spore-forming soil based microbe and it makes this delicious yogurt who would have guessed

00:49:32

uh that you can get at the store I believe both in U.S and Canada in in the US it's called florastor I'm sorry shift the jest of advantage so 15 something like that and all you

00:49:46

need is one capsule and so you buy it once um there there are sources uh yeah this is kind of hard to do in a

00:49:57

podcast but uh know that there are sources you can get these things from the the best thing is what I used to do in my neighborhood is I just have a party and I give you a little bit of it a couple of tablespoons of the yogurt

00:50:11

curds or whey solid or or liquid doesn't matter they both have microbes I give it to you a little container cover and here's how you get started uh so if you have anybody who's doing

00:50:24

this you can get started with that those microbes that's the best way when you have everybody doing it around you or your family or something like that uh if you don't have access to that then uh in my super gut book in my Dr Davis into

00:50:36

health.com blog it lists the source but we get the rotary from the company biogaya b-i-o-g-a-i-a or the U.S distributor averidus EV

00:50:48

eridis and I would buy the US for this product osf-o-r-t-i-s you can buy the gastrous product but the gastrous is if it's kind of a pain because it's made for babies you have to crush 10 tablets the osports

00:51:03

comes as a higher potency capsule 5 billion counts per capsule and one capsule you're off you're in business the gaseri uh Joe Mercola the doc

00:51:15

um so this came from South Korea and and then it was um acquired by a U.S company now Chris Hansen the the one of the world's biggest probiotic manufacturers and when you buy it from a manufacturer they want

00:51:29

you to buy like 100 kilograms for many hundreds of thousands of dollars We're not gonna do that so we wait for somebody a retailer Who's Got Deep Pockets you can buy those big minimum orders and Mercola did that he bought a bunch and sells it to you for a few

00:51:43

dollars as the lactobacillus gastorite bnr17 The Cutting Edge cultures also has an alternative form it's it's superfood El Gasser I think he calls it and that's

00:51:56

the 2055 strain from Japan that's a good strain also so you got two choices with the gaser eye all right go over that again all three of them just so we have it all in one neat little package here so lack bissell's rotary uh Google bio

00:52:09

guy you can get it from Amazon the easiest thing to do but it's bioguy at b-i-o-g-a-i-a us Fortis o s f o r t the reason it's called us Fortis by the way is because they conducted a clinical trial in uh

00:52:23

elderly lady 75 to 80 10 billion counts per day of the rotary versus placebo and the ladies who took the rotorite had 50 less loss of bone density

00:52:35

nothing else taken no calcium no vitamin D nothing just rotary and 50 less bone density loss so it's called us Fortis for bone and then the gaser eye you go from

00:52:47

Mercola Market or Cutting Edge cultures both strains work and then the bacillus coagulants gbi 36086 is Walgreens uh Target Walmart or

00:53:01

the equivalents in your part of the world um here it's called shift Digestive Advantage and uh just one capsule so you have to go through the hassle of getting it it

00:53:14

to my knowledge Jesse no one's like put it all together because it's three different sources three different companies now we are doing animal and human work because I I'd like come back in a year and say Jesse we've we found

00:53:26

several strains more that work and do it even better so comparative animal work first and validation humans but it takes it takes it takes time and money to do that because I'm not Pharma I don't have a

00:53:38

research budget of 26 billion dollars all right so we have these three different species you mentioned before the fact that these are bacteria that need to be at a warmer temperature to proliferate so we're going to make

00:53:53

the yogurt in something like a yogurt maker and once we have the combo of these three we can just use that as our starter culture the yogurt to continue to make it again and again

00:54:04

so when we ingest this coming back to something you talked about before there's two different areas that it's going to impact the way I understand it it's going to go down and to the lower Bell and help with the population there

00:54:18

help tame some of the bad guys down there and then also it's going to populate within the small bowel produces antibacterial compounds and kill the sibo directly there just so

00:54:32

you know I I concocted this hoping a handful of people would feel a little relief I did not expect it to have uh 90 or more success in doing better than

00:54:47

conventional antibiotics you know if you take xifaxin one it costs about twelve hundred dollars and the U.S not covered by insurance I'm not sure how it would work in Canada but it's very expensive a lot of side effects uh and you take it

00:55:00

for two weeks and its efficacy is 50 to 60 percent so if if I could have had 50 success with our sibo I would have thrilled so I did not expect that nearly everybody

00:55:12

responds and here's another thing too I I kind of regret calling it sibo yogurt because it makes people think you just take it to treat sibo but what we're really doing is replacing what's called keystone species very important

00:55:26

foundational species that you should have had from Mom at Birth an infancy but it got eradicated it so what we do is take it for four weeks or

00:55:39

if you had a really bad case some people say things like this I had to take antibiotics for three years uh continuously for my acne or something like that they have really messed up microbombs they might have to do the

00:55:51

yogurt for three months or four months and by the way you can co-ferment them all together some people like the ferment each of them individually if you do that the bacillus coagulance tolerates even higher temperatures of

00:56:03

about 115 to 122 degrees you if you co-ferment them we use 106 degrees only because even though it doesn't make bacillus coagulants the happiest we don't kill the rotary that dies at about

00:56:16

109 degrees so we compromise 106 and it seems to work just fine so you can co-format them together or some people like to do them separately and then combine them at time of consumption but to my great surprise

00:56:30

this really works but it really helps Also let's say you in four weeks ah you feel better here here's where it gets complicated if you're using the air device stop the yogurts for at least the rotary

00:56:44

for two weeks because the Rotary will generate a positive reading because it produces H3 gas in the upper in the small bowel very confusing but um uh and then you can resume it

00:56:57

once you test negative or if you know there's something you like if you have fat malabsorption or gas bloating and diarrhea or panic attacks if you have some index symptom is it oh it's gone you can be pretty confident that you

00:57:10

took care of it and then don't do it don't eat the yogurt every day maybe two or three times a week because sibo loves to recur and so far doing intermittent uh

00:57:23

consumption of the sibo yogurt especially rhodorant gas right seems to have been preventing most episodes of recurrence you're knee deep in this you've been doing it for at least a couple years now

00:57:35

we talked I think it was about two years ago how often are you taking the yogurt at this point about five times a week okay and have you noticed a difference

00:57:46

since we talked the first time taking it over that period of two years are you still noticing different changes as you extend out and continue to take it I think the

00:57:58

muscle restoring effect is greater so when I first did this some years back uh people think I I made this up I'm not making it up I gained 13 pounds of muscle in three

00:58:12

weeks and my strength went up by 50 so for instance Jesse I hate going to the gym so it's not like I'm hanging out at the gym all the time I hate going I go oh damn I guess I should go it's been a

00:58:24

week I'll go over 15 minutes to get the hell out like that so I'm going to the gym doing let pull down you know 130 pounds for 10 reps or so and then I ate

00:58:36

the yogurt within three weeks I'm doing 200 pounds for 10 reps I mean my strength this went way up here's here's what I'm seeing I think people who had more musculature in your

00:58:50

younger years like who knows 18 to 20 some I used to do a lot of that kind of stuff when I was a kid and I gained an extraordinary amount I've seen this people who are former athletes people who were not don't seem to get the same

00:59:02

big effect they might get something modest like six pounds but I'm seeing former athletes regain a huge amount of muscle and and strength so that seems to persist over time

00:59:13

uh libido you know um not just in me but in La I every Wednesday night I have a meeting with about 90 to 100 people via two-way zoom and I I said hey um this touched some

00:59:26

personal issues but if if you're willing to share have you had an increase in libido or in the erotic content of your dreams all these hands go up I said well

00:59:39

but you're willing to share right and a bunch of people said well my libido went up so much that I had to back down on the yogurt every second or third day because my partner couldn't accommodate

00:59:51

my needs guys get about a 50 rise in testosterone ladies can enjoy a restoration of vaginal moisture and um the lining and sensation

01:00:05

um just what scares me is going off the Rotary I moved about eight months ago and was extremely stressful extremely stressful

01:00:15

I got a bad case of seafo out of it small intestinal fungal stress can do that it activates fungal overgrowth and so I put myself in a course of berberine some other things and just common

01:00:28

anti-fungals the problem with anti-fungals is they can have antibacterial effects and a lot of the anti-fungals like berberine also kill off rotary so I'm a chronic Insomniac Jesse

01:00:40

terrible terrible sleep if I get rotorite sleep like a baby nine hours no interruptions incredible sleep when I take berberine as I did for the

01:00:52

sifo it kills off the rotorite and I'm back to laying down in bed at 11 PM laying there not sleeping a wink till 7 A.M terrible insomnia so I'm terrified of

01:01:06

going off the right or right and as long as on the rotary though sleep is magnificent let's stick on that berberine piece because the way I see it and understand it a lot of people are taking that to help regulate blood sugar

01:01:19

long term so in that case for somebody that is taking that at say their High carbohydrate meals to keep their blood sugar regulated you're talking about how it's going to be killing off you know

01:01:32

fungal infections which could be a good thing but then the bacteria including El rotori yeah so I think that's important we talk about it for somebody that is taking that thinking it's it's just to

01:01:44

their benefit there is also this impact on fungus and bacteria yeah I think a lot of people misinterpreted the evidence on berberine and curcumin also and some others in other words if you take let's say you take 100 milligrams

01:01:58

of berberine 100 milligrams of curcumin you poop out 99 milligrams yet there's no question these things have real biological effects like curcumin it reduces C-reactive protein levels in your bloodstream it reduces

01:02:10

knee or hip arthritis pain these things have real biological effects now wait a minute how can they work if there's virtually no absorption so this has prompted a whole effort to

01:02:22

let's add things to make it to force absorbance and bioparine and piperine and nanoparticle emotions uh I think what they're failing to see is that what they're really doing is Shifting bowel

01:02:34

floor composition and reducing endotoxemia if so if you have especially if you have sibo and you reduce endotoxemia you'll say things like my blood sugar is lower my knee pain is less those are endotoxin

01:02:48

effects and as you point out what's the consequence of taking some antimicrobial effects or extended period we don't know bad things could happen so I discourage people from taking these antimicrobials

01:03:00

unless it's in the setting of a limited period of time addressing sibo cifo endotoxemia all right so early on in the conversation we talked about what your diet looks like we're starting to get a

01:03:14

picture here of what you do to maintain your microbiome you mentioned five days a week with this yogurt I know you're a fan of having a diverse array of different fermented foods talk about as somebody on The Cutting

01:03:27

Edge here with the microbiome and I know you're an experimenter and a scientist when it comes to this what are some of the other things you're eating and doing to enhance your microbiome

01:03:39

so on my kitchen counter I have kombucha I've got bacillus quaglans fermenting in applesauce I've got bacillus quaglens fermenting in

01:03:51

um pasta sauce I've got a mixed fermentation uh mango passion fruit juice I've got saccharomyces bellardia oh I

01:04:05

should tell you about that so there's a very interesting fungus called saccharomyces bullardii it's a cousin of saccharomyces cerevisiae used to ferment wine beer but belardier is

01:04:18

better adapted to the human body but it's probably among those important things anybody can do to minimize the damage from taking an antibiotic so if you take an antibiotic it wipes out huge number of species well getting

01:04:30

saccharomyced bloody I oddly managed to preserve most of the microbiome not all but most well the odd thing about that is you can make a sparkling juice with it one of the things by the way when you

01:04:44

for Med you reduce sugar content you can eliminate short content too if you go long enough so what I do is take a capsule of a commercial preparation called florastor

01:04:57

f-l-o-r-a-s-t-o-r I'm not sure what it's called in Canada I might be the same though florist or one capsule into any volume of juice the pulpey or the juice the better like apple cider or a thick pulpy juice

01:05:10

yeah as long it doesn't have any preservatives no potassium sorbate no sodium benzoate and then uh cap agitate gently and then loosen the cap

01:05:22

because at 24 hours you're going to see it bubbling like crazy that's carbon dioxide and if you have it capped too tightly it will explode in your kitchen so keep it light or even burp it now and

01:05:34

then or you can go to the beer making store and buy these little vent caps for two dollars but uh keep it loose and go for 42 I'm sorry 48 to 72 hours long

01:05:48

enough to ferment most of the sugar out and then we consume a quarter a half cup a couple times during antibiotics more frequently because that's very important for preservation of your microphone it's

01:06:02

probably not a probiotic it's probably a Prebiotic that is bloodier does not take up residence but it seems to nourish bacterial species

01:06:14

and you know what if you ferment say um apple cider you get apple soda to attach it delicious so so that's one of the ones I have a couple of those fermenting also and you can ferment

01:06:27

ketchup sauces hummus salsa you can ferment all kinds of crazy things you know people in the Middle

01:06:37

East Europe and Asia there are pockets of people who still consume a lot of fermented foods you'd be surprised at the inventiveness of the things they one thing that a lot of us are a little bit too Swedish to do is ferment meat so if

01:06:50

you are in say rural Spain or Portugal in the Town Center they would put out a big spit of raw meat Jesse raw meat cover it with a rag and then come back in a couple of weeks

01:07:04

and cart take off a piece for men to be that makes me a little nervous but there are some people that might falling who do that too wow so given what you just shared how

01:07:17

much of what you consume percentage-wise would you say is fermented it sounds like you're fermenting quite a bit you know I I'm doing it also to learn and to get new recipes so it's not like you have to what I do but I would say

01:07:31

maybe a quarter of what I eat is fermented and if if you go back towards fermented Meats then it's even greater uh but a lot of us are too squeamish you can buy fermented Meats too but I think

01:07:44

one of the things I should mention is yeah because there's an increasing access to commercially fermented foods like fermented pickles fermented sauerkraut kimchi one of the things we have to accept is when you're

01:07:56

manufacturing something in a factory they're going to go as fast as possible right I'm always shocked that you can buy bourbon that's been aged 18 years imagine that business plan so so let's

01:08:10

say you're going to make sauerkraut well if you're making home sauerkraut you're probably going to ferment it for a minimum of two weeks well two weeks is an awful long time in a factory so they they ferment for much shorter

01:08:21

time so what I do is you buy a commercially fermented food like let's say sauerkraut leave it on your kitchen counter for a minimum of 48 Hours covered it's not longer and you look allow the

01:08:33

microbes to proliferate at room temperature if it's kimchi leave it out for at least two more days if not more let the microbes proliferate further and I think you do better yeah my good friend Donna schwank who's been

01:08:46

fermenting foods for 22 years is pretty much convinced if you ferment it yourself using a story culture that's therapeutically more powerful than most commercial preparations probably because of the higher bacterial accounts so it's

01:08:58

it's I think it's it's smart to do both some commercially fermented foods for convenience with extended fermentation on your counter and try to ferment on occasion something else and you can get delicious delicious recipes by the way

01:09:12

one of the tastiest recipes I've had is quarter Tomatoes or halved cherry tomatoes garlic cloves some green onions a sprig of rosemary and some cubed

01:09:24

eggplant uh you can use a starter culture or resident microbes Let It Go for about three days to five days the presence of tomatoes really accelerates fermentation otherwise it takes more like two weeks and I like to add a

01:09:37

little vinegar after it's fermented and then refrigerate and it's delicious it's absolutely delicious I like that and I love that hack I've never heard anybody talk about it to take the commercial uh say sauerkraut or

01:09:50

kimchi and leave it on the counter for a couple days that's that's brilliant and one thing I'll point out as you're sharing that when people are buying fermented foods people that are new to this you want to buy from the fridge

01:10:01

because usually they're sauerkrauts that have been pasteurized they're on the Shelf they're at room temperature the bacteria in those cases have been killed or at least greatly killed good boy yeah good point you you want to have

01:10:15

some indication that was fermented life contains live cultures naturally fermented or something like that there's no FDA regulation to my knowledge that makes them specify a specific way how do you feel about raw fermented apple cider

01:10:28

vinegar that you can buy at the store is that something you take in by itself or use in some of your ferments I'll use it so uh it's hard to use for cooking because when you hate it you kill it

01:10:40

um but it has some microbes in it has some microbial byproducts um you can use other kinds of vinegars also but apple cider vinegar is a fermented food so yeah it's a it's a good it's a good vinegar

01:10:52

well some people use vinegars for acidification of their stomach if they lost the capacity to make stomach acid it does not have to be apple cider vinegar it can be it doesn't have to be you can use other vinegars too to acidify the stomach in addition to your

01:11:05

butane hydrochloride and seltzers and stomach acidification when you lose the capacity make stomach acid is a really tricky problem tying to what we just talked about stomach acid and sibo but pivoting off

01:11:18

that leaky gut this is something that has a lot of controversy over it in the conventional world and even a little bit in the alternative world for somebody that is suffering from that

01:11:31

does doing a lot of we've been talking about today help heal the gut in that case yeah so leaky gut would be the same as endotoxemia it's increased intestinal permeability especially in the jejunum and ilium and you know I'm always

01:11:44

shocked you know this Jesse my my conventional colleagues are a generation behind so when I was talked to a very busy internal medicine doctor I said hey hey uh Jack how are you managing sibo

01:11:56

there's no such thing in other words he's going to ignore the hundreds if not thousands of high quality studies telling us oh yeah this is a problem it's been known for 30 years but it's been finally validated

01:12:09

now unfortunately one of the things we can't do is measure it clinically because the LPS endotoxin measure is not clinically available it's a research tool there are indirect ways to do it

01:12:21

but for for one of my colleagues to say oh it's unproven or there's no such thing is to be Reveal Your deep ignorance because it's not like there's

01:12:32

one study there's a ton of validation ever since Dr Patrice Kenny in Belgium first documented he and his group that serum LPS is a factor in driving insulin

01:12:45

resistance and other factors and other factors so uh it is a thing it it's like saying hey this gravity thing you can't see it how do I know it's real yeah jump off that building you'll find

01:12:58

out real fast right earlier you touched on probiotics and Prebiotic fiber that you can take in a supplement form hearing you talk about those I get the feeling that you're not a fan of either

01:13:12

you mentioned with the Prebiotic fiber it can actually cause issues so let's pull each of those apart separately Prebiotic fiber again touched on earlier it was not a good good case for it earlier was

01:13:25

causing issues but are there certain ones that you recommend with fiber in the diet complement that can be beneficial so you know there was a lot of debate

01:13:38

about nomenclature about how you name these things people say oh that's a type 2 resistance starch that's a polysaccharide that's a Prebiotic fiber that's a viscous fiber so what I what we've been telling people is don't worry

01:13:51

about that stuff those are biochemical debates all those things are provide nutrition to microbes so the sonenberg's the same people who did that study with the fermented foods they said yeah forget

01:14:02

all those crazy designations let's call all of them microbiota accessible carbohydrates Let's ignore what their biochemical structures but even that term does not encapsulate all the things that microbes metabolize

01:14:15

now so you need these things the problem is if you have sibo or dysbiosis in the colon you can't you can't take in let's say a galacto oligosaccharide fiber from

01:14:28

legukes like Black beans you can't say okay guys only go to the good microbes don't feed those bad guys so it feeds everything and so a common reaction you've got sibo let's say

01:14:41

30 feet of microbes you take some legumes or inulin Fiber you say oh oh it's stomachache diarrhea bloating Panic

01:14:54

anxiety nightmares that's because the unhealthy microbes especially if that reaction occurs within 90 minutes of consumption it's in this small so what you do there is back off

01:15:08

take steps to correct the sibo or dysbios like the Cebu yogurt or if you're inclined xifaxin and there's some herbal antibiotics you can also take only two regimens have been validated

01:15:21

um so take care of that first for at least a few days if not weeks then try to reintroduce those fibers so the fibers are very important we're learning this because there are people who are making the mistake on 4C Jesse of

01:15:32

eliminating those fibers they might call it a carnivorous diet or a ketogenic diet and the ketogenic diet is is one of the few diets we have lots of evidence for you know we suffer

01:15:45

from lack of real clinical studies and diet because it's very expensive we're not Pharma we we don't exploit people for money so we don't have you know a 200 billion dollar a year budget and so we have to hobble the other our studies

01:15:57

so if you eliminate those fibers from your diet weird things happen so it's like imagine you tie your dog up in the backyard and you didn't feed it for a week how's your dog gonna be

01:16:11

dead right so same thing if you don't feed the microbes the things they need like these fibers many species will either die off or diminish dramatically in numbers but there are exceptions one

01:16:24

exception is acromancia mucinophila mucinophil mucus lover so what acromancy that ackermans is a great microbe under normal situation where you're getting some fibers it's about five percent of your entire microbiome

01:16:38

sacromancia and it helps you control blood sugar and mood and reduce anxiety and give you better sleep so very good If you eliminate fibers other microbes

01:16:50

diminish acromancy of proliferates to occupy not five percent of your microphone but 18 24 36 44 becomes the dominant microbe and

01:17:03

it's acromancium eucinophila it eats your mucus so it leads to ulcerative colitis small bowel inflammation increased endotoxemia uh and long-term metabolic

01:17:17

derangements like weight gain fatty liver high triglycerides um in a diverticular disease in colon cancer so you don't want to neglect those fibers and the need for those

01:17:31

fibers is written into your genetic code if we look at all the wild hunter-gatherer populations of the world you'll see them digging in the dirt for roots and tubers grabbing wild plant

01:17:42

matter to to they don't know this but they're nourishing their microbiome should we continue that and don't make mistakes so kids there is a is a century-long experience with ketogenic

01:17:56

diets in children who have intractable grand mal seizures so this is a little four-year-old who's 10 seizures a day and she's just getting brain damage from it so Mom and Dad put her on a ketogenic

01:18:09

diet and it reduces seizure frequency by about 50 percent but what happens to those kids they stop growing these are children they develop osteopenia or osteoporosis

01:18:22

they develop kidney stones calcium oxide these are kits calcium oxide kidney stones they get constipated and they get those adverse changes in their microbiome and so we know with good evidence

01:18:36

that ketogenic diet if it neglects intake fibers there are some people on the ketogenic diet who are getting those fibers and that's okay that's okay but if you're saying I'm just gonna eat you know pork chops and spinach or something like that we're not getting

01:18:50

enough fiber then weird stuff happens that's where I was going to go keto keto diet with having some of the lower carb veggies your thoughts on that so you're saying that would be okay that works

01:19:02

there's not sufficient a lot of data on that but it's it logically it works what I don't know is whether there's some adverse changes and such things as hydrogen sulfide producing microbes like

01:19:14

desulfur vibrio uh D esophageal is a very bad microbe that probably causes colon cancer and it proliferates when you have a meat heavy diet uh I don't know if that's sufficient to

01:19:26

ablate the overproliferation of hydrogen sulfide producing species that's an uncertainty okay this opens up a lot of different questions we talked about the keto piece but moving to carnivore what is there

01:19:39

any studies showing what happens even say a month on that diet where there's no fiber he talked about the anchormancia and how that's going to proliferate but even in a short-term

01:19:51

basis would you say for 30 days and then if they were to go back to including fiber would you would you stand against that nobody knows how long you must deprive your microbiome of fiber before it

01:20:05

becomes irreversible it's just not known you can imagine how difficult that would be I suggest you okay we're going to put you in the group of people who do it for two weeks we're gonna put you and a group people do it for four weeks and

01:20:18

then we do extensive microbiome analyzes over time to see who can recover who can't so very expensive to do very difficult and huge amounts of data so to my knowledge no one has done that

01:20:30

now we don't want to get confused by by labels a ketogenic diet without fiber is a carnivorous diet so even though they sound different and the different products go with it it's essentially biologically the same

01:20:43

so I think we could safely assume that the diets that were ketogenic used in kids as well as adults that uh develop ketosis as you do on a carnivorous diet were extremely destructive

01:20:55

over time the the crazy thing about this Jesse is that in The Upfront period it lulls you into thinking it's good my waist shrunk by six inches my blood pressure went down my triglycerides went

01:21:07

down my blood sugar went down I'm clear I have energy up front because what they did was they starved their sibo the microbes in the upper GI tract that

01:21:20

were causing mind fog fatigue all that kind of stuff so the EV it's like um going on a low fodmaps diet just because you've had less bloating and diarrhea by eliminating FODMAP fiber and sugar does

01:21:33

not mean you've addressed the problem and you've righted your microbiome so I think what I'm trying to do Jesse is get everyone to think a little more clearly about what they're doing and it's always reassuring to me to think well how did

01:21:45

people used to do this before dietary guidelines before big food got in the way with their exploitative practices your great-grandmother did and that's

01:21:57

what they did you know they they they had root vegetables and vegetables they would ferment things and canned things when they ate an animal no one threw the brain away or the tongue

01:22:10

or the heart or the liver the kidneys you ate them and that by the way provided abundant quantities of collagen hyaluronic acid and other nutrients largely absent from the modern diet by the way ladies love

01:22:23

this when you combine rotary one of the effects of rotary besides upper GI colonization is to cause a hypothalamic or brain release of oxytocin which is incredible for skin health and other factors

01:22:36

when you combine rotary slash oxytocin with collagen peptides and hyaluronic acid you get a dramatic Improvement in skin Health ladies will say oh my crow's feet and smile lines

01:22:50

are now gone my sebum my skin is moister and my joints feel better because the hyaluron the rotorite and uh cartilage sorry and the um collagen

01:23:03

increased joint collagen the hyaluronic acid increases joint synovial fluid joint lubrication so that's a joint rebuilding formula also it's also a body composition modifying formula targeting

01:23:18

loss of abdominal visceral fat that's a source of most of the problems associated with overweight and restoration of Youth full muscle which is a huge Advantage long term in your health

01:23:30

so that that combination because you're supposed to in collagen you're supposed to get it from animals and by the way not from bone broth bone broth has been shown to be very rich in lead especially if you use vinegar to make it uh I I

01:23:43

urge people to use what I call carcass broth it sounds awful but so you buy a big baked chicken for instance you eat the meat eBay right and take the leftovers bones tendons ligaments any

01:23:56

organs any meat hanging on and make broth or soup other than that not just the Buns because if you use only bones and you break open the body so by the way for the bone marrow um if you use only the bones and use

01:24:09

vinegar you're getting some collagen teensy weensy bit of magnesium very small amount of calcium and a lot of lead so but that's another way to get collagen uh hyaluronic acid comes from

01:24:21

brain and skin nobody wants to eat brain anymore and I see these ladies buying boneless skinless chicken breasts right and paying 120 by the way for hyaluronic

01:24:33

acid syrup a little jar an ounce half an ounce and putting it on right oh smooth it washed it off at night no better so taking hyaluronic acid orally is a much more effective way for skin Health

01:24:46

joint health brain health Etc how do you feel about as you're talking about crow's feet and putting the hyaluronic acid under the eyes it gets me thinking about our skin microbiome how do you feel about

01:24:58

taking microbes and applying them to the skin and not just internally you know it seems to work Jesse so people will take things like kefir or one of the yogurts like rotary yogurt or even commercial

01:25:10

yogurt which hasn't always nothing in it but do it and there seems to be positive effects even with something like eczema but it's it's likely not from the microbes in the food it's once again so

01:25:24

if you if I put Luca stock mesenteritis and Peter caucus elected acetylacticide on my skin they don't take up residence but they somehow cause a positive shift in the skin microbiome but specifically

01:25:36

reduction in the nasty staphylococcus aureus and there seems to be a shift towards more beneficial microbes like its cousins staphylococcus epidermidis uh the whole skin microbiome as well as

01:25:49

uh mouth microbiome Airway microbiome bladder microbiome vaginal microbiome prostate microbiome all these things are only starting to yield to investigation

01:26:03

but it's it's proving so one of the most important things a woman can do so a third of the female population on this planet on this planet has vaginal dysbiosis disruption of the vaginal microbiot

01:26:16

which sounds okay so what dryness irritation funny smells and discharge well no miscarriage you lose your fetus premature labor and delivery if you

01:26:28

deliver a child at 30 weeks that child is going to have problems for a lifetime so it's not a small issue but it's believed that the vaginal microbiome is disrupted inflames the cervix and causes

01:26:39

it to relax prematurely and release the fetus throw the baby well one of the things that a woman can do is re the vaginal microbiome is very different from the gastrointestinal microbiome it's a vaginal bomb is very

01:26:53

discreet and definable and so ladies who uh have vaginal dysbiosis have almost all lost the dominant micro black Bissell is crispatis and have allowed proliferation of unhealthy microbes such as adipobium

01:27:06

gardnerella and E coli well a woman can take um Chris bottas there's only one product I know by the way and has Chris bottom some other species but it's called um gero femdophilus

01:27:21

but you wanted to have lactobacillus crispos the amazing thing Jesse the woman can take this orally and it colonizes the vagina there's no connection between the gas intestinal

01:27:33

tract vagina it somehow colonize the vagina it's be it's because of contiguity nearness in the perineum in the groin and then even more remarkably there's very good signs from Loyola Chicago that

01:27:46

a woman takes that crispatis colonizes the vagina and then colonized the bladder and thereby reduces a very bad problem for ladies which is repeated urinary tract infections it cuts them by about

01:28:00

50 not 100 but 50 not bad and it reduces what's called urge incontinence there's ladies who cough or sneeze or laugh and they pee very embarrassing right well

01:28:11

this Cuts back on that too so uh skin Airway all these microbiomes are yielding to investigation one of the areas we really know a lot more about is the oral microbiome second only to the colon and density of

01:28:26

microbes and what varies in conversation Jenny there's a microbe in the mouth called fusobacterium nucleotide it over proliferates it's okay to have normally but it over proliferates when

01:28:39

you have bleeding gums gingivitis or periodontitis where it then enters the bloodstream this is called translocation and colonize the colon and the evidence is very good it is a principal cause of

01:28:52

colon cancer colon cancer starts in the mouth incredibly and doesn't get there by swallowing gets her through the bloodstream translocation well that

01:29:04

means maybe the gastroenterologist should quit being so concerned about colonoscopy and start looking at your mouth microbiome oh and your colonic microbiome as well and

01:29:16

then devise ways to eliminate I have a a very good friend a dentist natural dentist in Oklahoma City Dr Debbie Osment Ozment by the way she's got a nice blog too uh podcast and she she tests she's a dentist but

01:29:30

she tests oral microbiome and if you test positive for fusel bacteria which will test your poop microbiome also she says in her experience there's a hundred percent correspondence

01:29:41

you have it and now she uses the common antibiotic and metronidazole to eradicate it though she's working towards a more natural solution is there something we can do that's microbial say to get rid of both areas but that's but

01:29:55

think about that that's a major cause likely for colon cancer but it starts with efforts in the mouth this is this is changing everything wow and as you talk about eradicating

01:30:07

repopulating when it came to the vagina we talked about populating on the skin and how you know there's changes that happen there if we're applying topically it gets me thinking about what we're doing to disrupt all this we talked

01:30:20

about antibiotics before but there's things that we're putting on our skin in our mouth things like mouthwash and and certain soaps that we're using on our hands and body so it's not just looking at it there's

01:30:33

two different sides to this one being not killing off what we have through these toxic things that we're putting in on our body and then also to repopulate and to work

01:30:45

with microbes to bring back the good guys to those different areas yeah I won't be and I'm not an expert just seeing toiletries and those kinds of things but I will say as a general principle you want to minimize use of

01:30:59

soap brings an absolute minimum any use of shampoos and of course try to buy the the products that had the least number of chemicals like like methyl parabens and all those additives

01:31:12

um try to avoid topical application of I think creams and such you won't need it by the way if you get rotary and oxytocin you're going to find uh you

01:31:24

don't need hand creams ladies like these things of course and uh most ladies who I talk to say they stop using facial moisturizers so this return to the natural way you know try to avoid using soap on your

01:31:36

face there's this thing called water you can use right so backing off a lot of things that people have gotten accustomed to mouth washes um my friend Debbie Osmond does said

01:31:48

let's say there's one mouthwash she tries to use I'm so I'm black in the name because it's not my area but but conventional mouthwashes are very harmful it's been well documented if you use a conventional mouthwash your blood

01:32:00

pressure goes up for a long time because you've eradicated oral microbes that you needed that were producing such things as night uh as nitrosamine not sorry as nitric oxide that reduces blood

01:32:12

pressure uh and and they're not selective for bad microbes they kill everything including good ones uh I don't yet know what we should do to restore a full microbiome in the mouth

01:32:25

one advantage is Xylitol the natural sweetener and apples and pears and Xylitol kills off streptococcus butans which is the primary cavity causer in the mouth it's also I I became aware of

01:32:38

this only recently a potent anti-fungal the sweetener Xylitol it itself is not anti-fungal but if you take it in the presence of those fermenting microbes like pediococcus and look at ostock

01:32:52

those microbes specifically convert Xylitol to a whole range of anti-fungal components so Xylitol could be a very interesting anti-fungal agent because we haven't talked that much about it but it

01:33:05

alongside sibo there is proliferation of fungi that's a big problem for a lot of people they're having sugar Cravings or having anxiety they have IBS like symptoms and anti-fungal agents

01:33:18

detecting fungal overgrowth is tougher than sibo there's no air device for fungi overgrowth you're stuck with either presuming you have it or doing a stool test and some of the agents are tough to take like the berberine I took when I moved

01:33:31

that was a rocky course I had a few really rough weeks not sleeping Etc so it's not fun and if Xylitol Works um I I think it does we need better evidence but there's lots and lots of

01:33:44

experimental evidence that suggest xylitol is fairly effective anti-fungal I hope that remains true and now they have Xylitol gum I don't know how you feel about that you know I think it's reasonable you know I always remind

01:33:57

ourselves the things that really work are things that were supposed to have been in your diet all the longer in your life so aspartame was never supposed to be in your life super low it's never supposed to be in your life but Xylitol was okay because you would

01:34:10

eat wild fruit that had some Xylitol in it a collagen you're supposed to be eating hardened tongue and liver and intestines and stomach getting lots of collagen so getting no

01:34:23

one wants to do it anymore few people want to do it so we get collagen peptides hyaluronic acid you're supposed to eat brain and skin most people don't do it anymore so we get while we're talking about repopulating

01:34:36

specifically I'm thinking back to the vagina piece and the oral that can repopulate down there it gets me thinking about taking that to the extreme fecal transplants so somebody

01:34:48

who their microbiome's been trashed and it's in a really bad spot taking poop from a healthy donor and implanting that in the person that's suffering how do

01:35:00

you feel about that some Kinks need to be worked out so they they screen for obvious things hepatitis C Hepatitis B HIV those kinds of things uh they're not screening for sibo which

01:35:13

I think is a major oversight because if you you take the poops onto the sibo you're transplanting what are called proteobacteria or enterobacteriation these are fecal microbes that are not good for you there have been I think a

01:35:25

couple of deaths from fecal transplant there's also this if you take the feces of an obese healthy person and Transplant to a slender unhealthy person that slendy person might have reduction

01:35:37

in baloney and diarrhea and get fat so you so that has to be worked out also um so I think what's going to happen is there's going to be fecal Banks where they screen people very thoroughly

01:35:50

not obese no uh cancers no HIV all that stuff but also no sibo and has a positive uh microbiome with proliferation of the species you want like fecalobacteria and acromancia

01:36:05

lactobacillus and that's what you transfer drawback it's a colonic transplant what about the 24 feet of small intestine what impact can you

01:36:17

expect fee and because you're it's like um putting your canoe Downstream hoping it goes Upstream right well it doesn't work that way so

01:36:30

if you put in colonic fecal material how effective will it be in the duodenum in jejunum 20 feet up so I I suspect it's a partial solution so better screening necessary

01:36:44

um and probably a partial solution and that's why I'm so thrilled that we're seeing these incredible effects just from this simple idea of sibo yogurt I might not to say that's a

01:36:56

solution to All Humans problems but you're you're going right with the battle is being fought in this small intestine Jazzy I'm surprised that there's not more talk about that there's in fact a very hyped up probiotic where they

01:37:09

double encapsulated to delay release into the colon that's not a good idea because if half the population a third to half the population has proliferation of fecal microbes in this small intestine you

01:37:22

want microbes to release with the small intestine because that's where the problems are starting right I hear you and last time we talked I asked you straight up are you taking a probiotic and you weren't

01:37:35

you've touched on probiotics a couple times including just now is there one obviously you're somebody that's doing everything fermented foods the yogurts and it's not just about a probiotic and

01:37:48

a silver bullet but are you taking a probiotic to complement all these other things you're doing you know we're going to look back Jess in a few years and say look at what we used to do with probiotics these haphazard collections

01:37:59

of microbes where we didn't know what the dose required was for True biological effect so if you're if you're micro let's let's take a study a recent study using the bnr17 strain of gasoline

01:38:14

Placebo given they're measuring waist circumference Placebo no drop and waist circumference one billion no dropping waste or coverage 10 billion three centimeters drop in Waist circumference

01:38:26

well that's as far as the study went well if 10 billion worked what would 50 billion have done 100 billion 500 billion a trillion don't know but so

01:38:38

right now we have so little dose response data what's the right dose we also don't have strain optimization data if atccc PTA 6475 rhetori works is

01:38:52

restraint it's better at it at say provoking oxytocin how about collaborative or Guild effects microbes like people you don't live by yourself in isolation you have a partner

01:39:04

and family and co-workers and friends and communities microbes are the same and that's why so if Mom gave you say rotary you'd have it for a lifetime provide you're not exposed to

01:39:17

antibiotics and other things but if you take it as the yogurt or or probiotic you have it for a few weeks why probably because you lack the whole Guild or Consortium or community that supports it so we don't have that yet

01:39:30

either so that's why the modern micro probiotics are just haphazard collections with no thought to collaborative effects and there's some other issues not factored in to crafting a modern

01:39:44

probiotic the closest we can come I know it was my my friends uh Martha Carlin and Raul Cano Dr Roe and by the way full disclosure they're a sponsor of my podcast

01:39:56

um companies Called biodequest bioti Quest and they have some products where they've at least theoretically combine microbes that have synergistic effects for instance they have a product called sugar shift that consumes fructose

01:40:10

glucose and sucrose in your GI tract and thereby presumptively reduces blood glucose so I gave it to 20 of my people non-diabetics I agreed to finger sticks for four weeks fasting uh and they

01:40:23

reduce their fasting blood glucose by 9.8 milligrams which doesn't sound like a lot that's a huge amount in fasting non-diabetic person it's on a par with metformin taking a drug

01:40:35

so and even more interestingly Martha's uh primary motivation is the fact that her husband has Parkinson's disease and he's had it for a number of years and there's experimental evidence not

01:40:47

human evidence that when you when um that product consumes those sugars it converts it to Mannitol humans can't metabolize Mannitol but it

01:40:58

can cross the brain where experimental evidence not yet human suggests it dissolves the alpha sin nuclean the stuff that accumulates in the brains of people with Parkinson's disease anecdotally she's given it to her

01:41:11

husband a bunch of other acquaintances with Parkinson's and they've had what appears to be partial remission including your husband who no longer needs a walker to get around he ambulates freely so she needs somebody

01:41:23

needs to do the clinical trial because that's such an important effect but that's a close I know of Jesse to something that's been intelligently crafted synbiotic 365 syn biotic 365 is

01:41:36

a pretty good product but uh they the one issue with that is the rotorized strain they include is what's called a 30242 strain I'm sorry about these numbers also called ual re-16

01:41:51

reason I tell you that is that is a non-bacterias in producing strain of rotary we don't want that one then right and so if you take symbiotic 365 either directly or make a yogurt out of it make

01:42:04

a yogurt out of the 6475 strain of rotary because you're not getting the bacterias in producing strain so I don't know I I can't say this product they got it right finally

01:42:16

it's not happened yet it'll happen it'll happen but I I reiterate that because I hear this too often oh don't tell me about my I take a probiotic you know no but that's not good enough

01:42:30

that's the least important thing you can do currently that's important so Point Blank you're not taking one right now you know I've played around so I've taken sugar shift I've taken one called equilibrium which

01:42:43

I would not recommend absolutely not recommend and a handful of others but I can't say you know isn't it cool Jesse when you do something you say oh this change things yeah I went wheat and grain elimination

01:42:56

I lost 38 pounds my triglycerides went from 400 to 40. my blood sugar fasting went from 118 to 82. you know

01:43:08

were life-changing vitamin D no more seasonal affected disorder uh my I don't I don't burn anymore when I get sun I I tan instead were life-changing effects rotary I

01:43:23

sleep nine hours my libido's higher my skin is different you take a probiotic um maybe you know I have seen good effects from the sugar shift that's the only one I've I've seen and there's there's some

01:43:38

other ones that Martha and Roe will have formula and one's called Simple slumber and there's one called antibiotic antidote I'm not clear on the signs exactly but people I'm getting a lot of reports back from my my audience are kind of like you

01:43:52

and me don't buy sugar shift ferment it to Yogurt you know and get a ton of those micros So What by the way what you're doing with the micro when you fermented as yogurt it we don't care if it's called yogurt or not we just want to

01:44:05

increase the bacterial counts I I say that because people will say this people who don't know what we're doing they say oh Davis is not doing the right way that's not how you make yogurt we're not trying to make yogurt it looks and smells like yogurt what we're really

01:44:19

trying to do is taking a microbe or microbes and boost their counts dramatically so you can start with maybe a billion and end up with 300 billion I've taken

01:44:31

up to a trillion of rotorite we just want greater counts for greater benefit all right when you start talking about upping it all the way to a trillion it gets me thinking about is there a

01:44:44

certain limit that becomes too much or is the food the sugar that that bacteria is going to be eating off the medium whether it be you know dairy or or coconut will that be self-limiting

01:44:56

because it'll run out of food you know as long as you're not on cancer chemotherapy or have some other immune system impairment probably not to my knowledge

01:45:07

never has there been a effect of an excess number of of microbes probably because when you even if I took a trillion it's going into an environment of

01:45:20

hundreds of thousands of trillions so it's like taking a big bucket of water and pouring into the lake will the lake rise not really you know you're it's just it's not that much we it sounds like a

01:45:33

lot like the bio guy gastrous tablets made for babies there's a hundred million sounds like a lot but in microbes it's a nothing it's nothing and look look at

01:45:45

the bnr17 waste reduction study no effect a billion and billions uh you know a thousand million it's a lot but a microbe it's not 10 billion you start to see an effect

01:45:57

so what would a 100 billion what would a thousand billion do a trillion so this is all being sorted out now it's it's happening not as fast as I'd like to because when we have if if you and I

01:46:10

were drug companies and we had a new drug we test 0.25 milligrams 0.5 1.0 1.25 1.5 1.75 2.6 because you have an unlimited budget we can't do that every

01:46:21

arm we add may add another twenty thousand dollars and if our budget's only four hundred twenty thousand dollars for the next two studies we have to cut out some of them at the little things we'd like to do

01:46:33

well one thing that's becoming so apparent as you share different stories and and talk about all this is the power of the microbiome when you talk about things like the fecal transplant and and a fat person transferring to a skinny

01:46:47

person and then them becoming fat and and taking in oral uh bacteria and impacting the vagina and on and on all these different stories impacting the brain the Parkinson's case

01:46:59

what we do know is this stuff is powerful and it's still the early days in the big scheme of things and it's just exciting to to talk about and be part of this and to play around and experiment at this point

01:47:12

where there's a lot more to be learned you got it Jesse you put your finger on so I try to emphasize people this is a revolution it's changing everything you know I'd be

01:47:24

really nervous if I was a pharmaceutical company representative uh or executive and you're starting to see that these people playing around the microbiome are achieving extraordinary things a woman

01:47:37

can prevent miscarriage or premature labor with a probiotic there's now five microbes I'm aware of that can synergize to reduce uric acid hyperuricemia

01:47:50

very common risk for cardiovascular disease dementia of course gout some other things well now you can reduce it with microbes we're close to getting a collection of microbes that are very

01:48:02

effective at reducing oxalate for calcium oxalate kidney stones the list is growing of microbes that improve um depression or anxiety look what we're doing with rhodorite reduction of skin

01:48:15

wrinkles vaginal moisture boost and testosterone acceleration of healing restoration of a youthful immune response restoration of youthful muscle yeah you're right it's getting really

01:48:26

powerful and what I love is many instances they're Superior to Pharmaceuticals pharmaceutical energy has had its run and they're continue to exploit the public

01:48:38

with most recently with a GOP agonists like wegovian Manjaro and ozempic even though I think they never should have been approved at all because they're garbage even though my colleagues are telling their patients It's Magic it's not magic it destroys

01:48:52

your health but they didn't see the long-term outcome data I don't want to talk about that but it's a whole story of its own so I think we have a superior microbial formulation to gop1 agonists

01:49:05

I know we got it part way soon but a couple more areas I want to touch on before we do and when we talked about keto and carnivore it brought up for me intermittent fasting so we're starving

01:49:17

quote unquote the gut microbiome for a period of time but if we're doing say like a 16-8 fast intermittent fasting what does that do to the microbiome and are you a fan of that

01:49:30

you know judging by metabolic effects there's probably one of the things one of my uncertainties is a lot of the benefit presumed benefits of time restricted eating or intermittent fasting

01:49:43

seem to be minimized in the context of what my group is doing that is wheat and grain elimination restoration of nutrients to address insulin resistance and inflammation and

01:49:55

then addressing the microbiome but specifically restoration of beneficial microbes and reduction of sibo endotoxemia what's the benefit of time restricted eating and or intermittent fasting in that context

01:50:08

I think it's small what if you eat at McDonald's twice a week eat pizza uh have a big bowl of pasta a couple times a week in other words have a fairly awful diet then those methods do

01:50:21

have bigger effects because your diet's horrible so I'm just not sure and I don't know I don't think anybody knows where the adverse effects on the microbiome occur how long do you have to do it's probably

01:50:34

weeks though it's probably not hours or days it's probably weeks because it takes that long to see a lot of healthy microbes die off and allow microbes like acromancy to over proliferate so it's

01:50:46

probably weeks but once again no one's done that kind of Serial study to see where the timeline exactly is it two and a half weeks or don't know all right last piece we'll end on this supplements and we talked about

01:50:59

berberine curcumin vitamin D probiotic supplements we've touched on a number of them but before we part ways when it comes to the microbiome or beyond what are some supplements people should consider

01:51:13

well you know I'll make this issue Jesse that there's a lot of nutrients that are going to fall by the wayside because they're produced by microbes if you have a healthy microbiome

01:51:24

so that includes vitamins B1 B2 B3 B5 B6 B9 B12 K2 and C in other words a lot of stuff that people take K1 and K2 that your

01:51:37

microbiome that's their job to make those things and so I think that's what's going to happen as we get better control better restoration of the microbiome that we don't need to take K2 we don't need to take riboflavin or thiamine or folic or

01:51:51

folate so that's one issue that has to be worked out a little bit better though so the the nutrients I focus on are the things that you're supposed to get whose need is programmed in your genetic code

01:52:02

but you're not getting because of modern Lifestyles you're not getting magnesium because you drink filtered water and if they grew your plant in a hydroponic garden there's not much magnesium vitamin D the reason we talked about

01:52:14

earlier insufficient exposure to the sun wearing clothes working indoors losing the capacity activating vitamin D in the skin after age 40 iodine because it's only in shellfish and seafood but we we

01:52:28

can't eat those things anymore ad-lib because of mercury and cadmium so we get iodine so um uh um where I left out vitamin D

01:52:39

magnesium iodine oh omega-3 fatty acids uh we can't eat fish like we want to if we do we get murky poisoning so we rely on omega-3 fatty acids and then other things lacking are kind of

01:52:52

optional but because we're not because the low-fat era screwed up our diets and people stop eating organs so you can try you can consider getting more collagen and hyaluronic acid

01:53:04

um and a lot of so a lot of things are changing so I I would favor restoration of the of the nutrients that are lacking in Modern Life and I I also tell people to get away

01:53:15

from this idea of treating things so what we're we're not treating diabetes we're not treating hypertension we're not treating rosacea instead we're addressing these common factors that are

01:53:29

lacking or disrupted in Modern Life that when corrected whether it was labeled rheumatoid arthritis or fibromyalgia or type 2 diabetes or obesity it goes away

01:53:41

they all go away or at least recede and so it's a very different concept than treating things that there's a time and place for treatment also but for the most part for the vast majority of modern chronic

01:53:53

diseases that plague modern people addressing those common factors that allow disease to emerge in the first place is a far more uh effective strategy I think I hear you perfect place send it Dr

01:54:06

Davis really enjoyed the conversation always enjoy our chats thank you for coming back on the show and keep on doing what you're doing it's needed now that you're done my conversation with Dr Davis you're going to want to stick

01:54:18

around here and catch my chat with Tim he's got a lot more to share about the gut microbiome you don't want to miss this I'll see you over there I think I think we've gone far too far the wrong way and we need to

01:54:29

get back to much more natural methods